AI in drug discovery – what it is, where we stand and the path forward

Show HN: Mic Drop, a real-time multiplayer karaoke game

The free online version of Grab the Mic: get a word, buzz in, and sing a real song containing it — your friends vote. No app, no mic needed, 2–8 players.

RISC-V: They Should Have Known Better

Dmitry.GR: I am often asked to explain my distaste for RISC-V. Here it is.

A fortuitous decade as an indie software developer

Tracking down a Zsh history data loss bug

For many years, I sometimes discovered that commands I was sure I had run were no longer present in my Z shell history file (~/.zsh_history). In this article, I will show you how I tracked down the bug. Spoiler: ultimately, patching Zsh to make it crash loudly and analyzing the crash’s core dump was the winning strategy!

Asus Bike Booster

ASUS Oxiis E250G1 transforms any bike with 500W peak boost, 50 km eco range, app control, fast USB-C charging, and easy install now for riders

Numba in the Browser: Unlocking a New Scientific Python Stack in JupyterLite

A JIT compiler and its scientific Python ecosystem running entirely in the Web browser

At-home test for infected ticks could improve Lyme Disease diagnosis

LymeAlert will hit the market in August. The latest tool against the tick-borne illness could become a medicine cabinet staple

Guiding Ships with Moire Patterns

I was inspired by Tom Scott's excellent video and links here https://www.youtube.com/watch?v=d99_h30swtM   where he talks about a particular type of "Inogon" light used to guide ships through channels or harbours. The patent is here: https://patents.google.com/patent/US4629325 and the military report on the effectiveness is here: http://www.dtic.mil/dtic/tr/fulltext/u2/a168108.pdf (Hint; They don't seem to like it much). I decided to build…

Super El Niño Keeps Growing as New Forecasts Reach Record Territory Ahead Winter

Super El Niño keeps strengthening as new forecasts push toward record levels, shaping Winter 2026/2027 patterns across the U.S. and Canada

Software Engineering fundamentals matter more

The manifestation of my imposter syndrome, for me and today, is what does it mean to be a software engineer. There's a lot more noise than signal on the Internet about agentic engineering, what can be accomplished, and its implications for the future. The title I chose rather gives it away; it's about choosing —…

Abdominal fat predicts heart disease risk better than BMI

AI has access to a vastly larger working memory than the human brain

The key advantage may not be superior reasoning, but a virtually unlimited symbolic working memory.

Cultivating a state of mind where new ideas are born (2023)

Solitude, creativity, Bergman, Grothendieck, and the pursuit of great ideas.

Tea5767-Radio-Tuner

ESP32-based FM radio with TEA5767 tuner, KY-040 rotary encoder, PAM8403 amplifier, and 0.96" OLED display. Custom PCB design. - turtushig22-blip/tea5767-radio-tuner

Semaglutide linked to lower predicted dementia risk

Show HN: Laptop is the last place your secrets are still in plaintext

Find the plaintext secrets on your Mac and move them behind Touch ID, injected just in time without breaking the tools that read them. Free and local-first. - jitpass/jit

Zapping Rocks Unlocks Stimulated Geologic Hydrogen

Eden GeoPower breaks rocks with electricity to unlock stimulated geologic hydrogen, a vast source of clean energy from pulsed-power rock fracturing.

Asynchronous I/O in DuckDB: Work, Thread, Work

Starting with v2.0, scheduled for fall 2026, DuckDB will support asynchronous reads of Parquet and CSV files. This can significantly speed up queries when synchronous I/O does not saturate the available bandwidth, as is typical in EC2/S3 compute-storage setups.

Patterns and problems in emerging multi-agent systems

We ran experiments on swarms of Claude agents and found coordination failures, collusion, and sabotage. Here, we share what they mean for AI safety.